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23 January 2017

Committed to strengthening the antibiotic arsenal

The European Lead Factory (ELF) is boosting the discovery of new drugs by making high throughput screening and a quality compound library available to academia and biotech’s. To be eligible, the proposed project has to meet certain conditions. For example, the project should be considered as innovative and it should be possible to optimize the associated assay for high throughput screening.

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19 January 2017

PDE4NPD and the European Lead Factory team up: parasite enzyme up for ultra-HTS against 450,000 compounds

With help of the European Lead Factory, the Phosphodiesterase Inhibitors for Neglected Parasitic Diseases (PDE4NPD) project takes the next step towards developing novel drugs against kinetoplastid parasites such as Trypanosoma brucei, the causative parasite of African sleeping sickness, and Trypanosoma cruzi, causing Chagas disease. Together, PDE4NPD and the EU Lead Factory will screen 450,000 compounds for their potential to inhibit one of the parasite PDEs the project has validated. 

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19 January 2017

A blueprint for public-private partnerships in early drug discovery

A recent review in Frontier in Medicine describes the outcomes and learnings of the first 3,5 years of European Lead Factory (ELF) operations. It gives an overview of the unique characteristics and results of the programme: ‘ELF enables breakthroughs in areas with unmet medical and societal needs, where no individual entity would be able to create a comparable impact in such a short time’.

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16 December 2016

Sharing compounds in the Sharing Economy

The latest issue of BioCentury Innovations focuses on open innovation within early drug discovery and compound sharing, with the European Lead Factory as one of the best practices, with the largest compound library openly available. More and more pharmaceutical companies open their compound libraries in collaboration with the external community and/or other companies. 

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01 December 2016

PhD thesis enhanced with EU Lead Factory results and compounds

The European Lead Factory is proud to announce the first doctoral promotion based on compounds screened with the EU Lead Factory project. On 1 December, Freek Janssen defends his thesis on drug discovery and target validation for the Leiden University.

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23 November 2016

European Lead Factory drug-like hit leads to creation of a spin-out

Dr. Margit Mahlapuu, one of the academic researchers who has benefited from EU Lead Factory screening activities by identifying a drug candidate series for type 2 diabetes, went on to create a spin-out company based on these results.

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21 November 2016

Early Career Researcher Event in Lisbon, Portugal

The EU Lead Factory opens its doors again for young researchers from across Europe

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17 November 2016

ENABLE takes on Oxford antibiotic resistance programme

The University of Oxford takes the next step in targeting antimicrobial resistance, with help of the results and hit compounds delivered by the European Lead Factory. The Oxford team, led by Professor Chris Schofield, has got the opportunity to collaborate with the European Gram-Negative Antibacterial Engine (ENABLE) project to further progress this programme towards clinical development.

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01 November 2016

Euronews interview on EU Lead Factory now available online in 13 languages

Business Planet Magazine interviewed Dimitrios Tzalis (Founder & CEO of Taros) and Jan Skriwanek (Innovative Medicines Initiative (IMI) state representative of Germany) on the role of SMEs in the EU Lead Factory.

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26 October 2016

EU Lead factory broadcasted in Business Planet Magazine of Euronews

Dimitrios Tzalis (Head of Chemistry & CEO of Taros) and Jan Skriwanek (Innovative Medicines Initiative (IMI) state representative of Germany) explain all about the EU Lead Factory and the role of SMEs in an upcoming Business Planet Magazine interview that will be broadcasted this week on Euronews.

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